• Silymarin : Silymarin is the extract of Silybum marianum, or milk thistle, and its major active compound is silybin, which protects the liver against toxins, activates protein synthesis, and stimulates growth of new liver cells to replace those that are dead or damaged. It also has strong antioxidant (destroys oxygen free radicals) and anti-inflammatory actions.
It may be useful in preventing or treating gallstones by thinning the bile. Many dogs with inflammatory bowel disease (IBD) have concurrent inflammation of the liver/bile system and the pancreas. This suite of symptoms is called “triaditis” . Because silibin’s beneficial actions concentrate on the liver and bile systems, it may also be helpful in dogs with IBD.
Silibin has ability to preserve the supply of another important antioxidant, glutathione. which is stored primarily in the liver, naturally declines over time, and depletion of this protein appears to accelerate the aging process.
One study demonstrated that silymarin binds to a steroid receptor and it is hypothesized that structural similarity with steroids permits binding. Silymarin then, like steroids, may be able to modulate RNA synthesis. Additionally, one study in rats suggested that silymarin can also enhance deoxyribonucleic acid synthesis and, therefore, possibly enhance hepatocyte regeneration. Thus far, one study demonstrated hepatocyte regeneration in rats with silymarin.

• Artichoke : Artichoke flower extract has three active constituents, cynarin, luteolin, and chlorogenic acid, that serve as a pre- and probiotic to aid in digestion, as an antioxidant to support the hepatic, biliary, and cardiovascular systems, and also as a diuretic for renal support.
The action of artichoke on the liver begins with bile, but it certainly doesn’t end there. Artichoke extracts may help to protect the liver from various toxic assaults such as peroxides and carbon tetrachloride. Artichoke’s benefits on liver are often attributed to the antioxidant activity of the caffeoylquinic acid phenolic compounds and flavonoids such as luteolin and apigenin. Artichoke extract may be able to defensive glutathione levels in the liver, when exposed to oxidative stress.

• N-acetylcysteine (NAC) : N-acetylcysteine (NAC) is a chemically modified form of the dietary amino acid cysteine. NAC contain sulphur, and sulphur-containing amino acids function as antioxidants. Other sulphur containing antioxidants is glutathione. Glutathione levels are considered the most reliable indicator of the body's resistance to oxidation, and NAC plays a role in glutathione metabolism. NAC acts as a precursor to glutathione, NAC probably has more of a sparing effect on glutathione. That is, it neutralizes oxidants in place of glutathione, allowing glutathione levels to be maintained.
NAC is believed to reduce drug’s toxicity (Specially acetaminophen). Acetaminophen, a commonly used anti-inflammatory and pain killer, is quite toxic to small animals, especially cats. NAC has long been used to counteract the anemia that occurs following oxidative damage by acetaminophen. Other potential applications for NAC include the treatment of degenerative myelopathy, respiratory disease, chronic renal failure and feline immune deficiency virus (FIV).

• Coenzyme Q10 (CoQ10) : Coenzyme Q10 (CoQ10) is coenzyme is found in mitochondria, which is the powerhouse of the cells in the body. The coenzyme acts as a neutralizing antioxidant in the cell which protects the cell from damage and helps in metabolism. The natural production of Q10 in body cells tends to diminish with age and due to certain health conditions as well. Since it is an important antioxidant required for metabolism and maintenance of the cell thus over time it becomes essential to consume it in the form of supplements.
CoQ 10 is the key cofactor in electron transport chain. It was achieved that CoQ10 by its anti-oxidant, anti-inflammatory, and anti-apoptotic effects can have a therapeutic role in acetaminophen hepatotoxicity as well as metabolic- stress-induced liver damage.

• L-Orinithin L-Aspartate : L-Orinithin L-Aspartate is an amino acid that is mainly used in urea cycle in the capacity of removing excess nitrogen from the body. It is also very important in the removal of ammonia (NH3) by converting into urea, a waste product of cellular metabolism, from the body. This is known as urea cycle or ornithin cycle.
It may effective in chronic liver disease and hepatic encephalopathy (poor brain functioning) Cirrhosis is a chronic disorder of the liver.  L-ornithine L-aspartate lowers blood ammonia levels and so may have beneficial effects in hepatic encephalopathy or help stop them developing it.
In acute liver failure (ALF), high blood ammonia levels have been documented that correlate with mortality and complications. L-ornithine L-aspartate (LOLA) reduces ammonia levels by increasing hepatic ammonia disposal and its peripheral metabolism.

Ingredients (Per 10 ml) :

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• Silymarin : 140 mg

• N-Acetylcysteine : 200 mg

• Artichoke : 70 mg

• L- Ornithine L-Aspartate : 50 mg

• CoenzymeQ10 : 10mg

• Inositol : 10mg

• Vit.B1 : 1.4mg

• Vit.B2 : 1.6mg

• Vit.B6 : 1.2mg

Packing :

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• Per box contains 3*10 Chewable Tablets

Suggestions for Use :

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• 1 to 2 tablets three times a day or as directed by the veterinarian.